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hence, cautious selection is needed when applying these findings in clinical practice
Interestingly, the SUSTAIN program showed for the first time that GLP-1RA might induce an acute drop in the eGFR slope resembling the pattern observed in established nephroprotective drugs such as SGLT-2i, angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) [17]
Real-world results are somewhat lower for both medications but the advantage for tirzepatide holds in practice, not just in studies
For a researcher, they are two complementary tools, provided one never loses sight of the fact that these are compounds intended for laboratory use, not human application
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